Going off Anti-PD-1

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Going off Anti-PD-1

by lsv12 on Fri Oct 20, 2017 02:12 AM

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Has anyone before being dx as NED come off the Anti-PD-1?

My husbands onc keeps asking how much longer he plans on being on it.  He has had great success with this treatment. He has been on it for the past 4 years, dose #88. He has gone from 17 tumors with all but 4 still visable on CT scan.  They are quite small, thats why onc wants him to stop treatment. Outr question is ---- should he stop treatment without hearing that he is NED? Is he now taking it for no reason?

RE: Going off Anti-PD-1

by Chucksan on Fri Dec 29, 2017 09:48 AM

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IMO and experience do not go off the anti PD-1 (perhaps Opdivo or Keytruda?), unless he has severe side effects.  My wife is now been in NED (remission) for 14 months after about 3.5 years of treament with Opdivo for stage 4 squamous NSCLC (this was after two failed combo regimens of chemo).  Opdivo like Keytryda were both originally developed for melanoma.  The last year of Opdivo or so she went from every two weeks to every 4 weeks, every 6 weeks and then every 8 weeks.  A PET/CT scan before another infusion showed NED.  I believe she might have been cancer free slightly earlier (the oncologists was hesitant to order the PET/CT, too expesiove he said even though our insurance covered it.  We pressuted him and he finally ordered the PET/CT scan.  IMO the perhaps extra infusions might give better odds that the cancer does not re-occur.

Sounds to me like he might have been on the drug for about 3.5 years or so (at one dose every two weeks ... I sure hope he has an implanted chest IV port).

My thoughts:

..... Have the treatments spaced out to every 4 weeks and perhaps longer later, etc. and watch the scan results.  The drug protocal might say definitely every 2 or 3 weeks but the oncologists can use his descretion.

..... Ask the doctor if he has any other maintenance suggestions to keep the cancer from progressing again in the future other than wait and watch.  Sometimes the drug might contiune to work quietly down the road but on the other hand I might fear that if he goes off the drug it might slowly come back or metasticize.

..... Get a second opinion.  We did at first and it was no problem and we ended up with a great onoclogist.

All The Best

RE: Going off Anti-PD-1

by jack123 on Sat Jan 06, 2018 07:00 PM

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Anti-PD-1 is new study.. I actually just found it and I am kinda optimistic about this... Take a look about this research here

http://www.evolving-science.com/bioengineering/new-hope-old-

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