Any way to improve standard chemo efficacy?

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Any way to improve standard chemo efficacy?

by lililiu6 on Wed Feb 14, 2018 06:11 PM

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Hi, Everyone:

My sister was diagnosed with stage IV pancreatic cancer stage IV (pancreatic ductal adenocarcinoma) in December. She was given FOLFIRINOX first. Seems she responded after the 1st treatment, especially her back pain was gone after irinotecan. But the 2nd infusion does not seem to be as effective. Her CA199 keeps going up and CT scan showed new tumor in lung and tumor is bigger in pancreas even the mass in back is not noticable anymore. Then she is told to switch to Gemcitabine and abraxane.  Again the second time seems to be less effective than 1st time.

Any way to improve the standard chemo efficacy?

Anyone tried hyperthermia or vitamin C IV during chemo?

Anyone tried taking cannabis oil for cancer treatment and chemo side effect management during chemo cycles?

Any information is highly appreciated!!

lili

RE: Any way to improve standard chemo efficacy?

by jend013 on Fri Feb 16, 2018 05:39 PM

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My mom was diagnosed with Stage IV in August.  Did about 2 cycles of Folfirinox, similar story.  Looked like it was working, lung nodes disappeared, then tumor grew a tiny bit.  She then started Gem/Abraxane one treatment.  Through a lot of research, and tumor profile that showed a mutation in a gene that could have sensitivity to cisplatin, we were able to convince the oncologist to add cisplatin to the mix  

Some research on that here: 

http://ascopubs.org/doi/abs/10.1200/JCO.2017.35.4_suppl.341

http://www.ascopost.com/issues/april-10-2016/phase-ibii-stud

After that, we then added a high dose of synthetic Vitamin D.  See short video about that here: 

http://www.onclive.com/onclive-tv/dr-ocean-on-the-importance

My mom is working with the team that came out with that 3-drug regimine, but we were able to get it worked out to get the vitamin D through her local doc, then the 3-chemo drugs at the local chemo clinic (in Kansas).  It took some work to get it all in place.    It seems to be working for her.   

RE: Any way to improve standard chemo efficacy?

by lililiu6 on Fri Feb 16, 2018 09:11 PM

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Thanks for the reply!

Do you know which mutation in your mom's gene makes you feel she might be sensitive to cisplatin?

We asked my sister's doctor on this triplet regeme. He said my sister might not respond to cisplatin since she is not responding to oxaliplatin which is platium based.

What dose of vitamin D your mom is having?

Do you know which is the two made the difference?

Any information is highly appreciated!

lili

RE: Any way to improve standard chemo efficacy?

by jend013 on Sun Feb 18, 2018 04:23 AM

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The tumor had a single mutation - BRIP1.  It's in the same family (I'm sure I don't have the exact word) as BRCA, and it did not take a lot of research to find that BRIP1 and mutations like it were associated with sensitivity to cisplatin (or could be).  

I had the same conversation with the oncologist about oxaliplatin and cisplatin.  I found this article (I can't access the whole thing) which seems to say they have different mechanisms: https://www.nature.com/articles/nm.4291

I know my mom started feeling better after the addition of cisplatin, before vitamin D.  I am not sure of the dose.  Honorhealth/Borazanci gave our local doc that info.  If you search in clinical trials.gov I think you can find some info on it if you search for honor health's trials.  They are using it in several trials.  I do think it has made a difference, the last scan showed less inflamation and her pancreatic duct went back to normal. 

Has your sister been checked for a germline mutation?  Or had the tumor profiled?  She's awfully young for this.  Might mean she's carrying a mutation that predesposes her, and which might point to a treatment option.  I saw your other post. I highly recommend Dr. Borazanci.   I have also read good things about Alyson Ocean, who is involved with "Let's Win PC"  I believe she is in New York.  There is also NaGourney cancer institute that will grow a tumor sample and test for sensitivity.  That's kind of in our back pocket.  PANCAN even mentioned it. 

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