using fluorouracil 5% cream on lips

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using fluorouracil 5% cream on lips

by parkway on Tue Apr 03, 2018 10:57 PM

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Dermatologist prescribed Fluorouracil 5% cream to use on my lips since he diagnosed my lips as being pre-cancerous.  There were no sores on my lips, but I have been getting them checked yearly, as well as rest of my body due to over exposure to sun.  Wondering if it is safe to use on lips, as directions on product warn not to use on mouth.  I am applying very light film on lips with q-tip.  Product dries quickly.  Also concerned that product will somehow get ingested when I eat and drink.  I am drinking mostly with straw now & try to be careful not to get food on lips when eating.  Has anyone been instructed by dr to use this product on lips?  I have used for 3 days now and not noticed any change in color or sores on lips yet.

RE: using fluorouracil 5% cream on lips

by jayjay43 on Thu Aug 16, 2018 01:23 AM

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Parkway, I was searching for the same thing you asked about in your post, about lip application, as I am in the same boat right now, having to apply the 5% cream to one very small spot on my upper lip. 

How did this go for you? How long before you saw any sign that the cream was taking effect? I am on day 4 right now with not much appreciable difference in appearence. I also have trouble keeping it on my lip during the day while I'm at work so I'm applying it mostly at night before bed. I'm wondering if it's staying on long enough.  Any tips on what worked best for you?

RE: using fluorouracil 5% cream on lips

by zipper2544 on Fri Aug 17, 2018 02:08 PM

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I started this regime on Aug 1st, I'm into day 17.  It took about a week to see that it was really working, and it is.  Lips are blistered, cracked and bleeding.  Very painful.  I use the Fluorouracil only at night, apply light film on upper and lower lips.  During the day I use a lot of vasaline and aloe vera (pick a leaf from the garden, store it in frig toget it cold, cut a piece off and rub it on my lips.... that really works well. 

RE: using fluorouracil 5% cream on lips

by jayjay43 on Tue Aug 21, 2018 05:16 PM

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Thanks Zipper. Good to know what has worked for others. Finally noticing the redness and discomfort. I probably put on too thick a layer at night and it must have traveled down to my lower lip which is now red and sore too. :( I guess I have a couple more weeks of erosion and healing to look forward to. Hope your healing goes well. Good luck and thanks again for your reply.

RE: using fluorouracil 5% cream on lips

by zipper2544 on Tue Aug 21, 2018 07:10 PM

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Jay,I also use a q-tip to apply at night.  Seems to put it where it needs to be more accurately.  Good luck!!

RE: using fluorouracil 5% cream on lips

by Jlynnr on Wed Aug 29, 2018 08:49 AM

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Zipper, I started the process on August 15 and am 14 days into it. My lips are blistered cracked and bleeding just as you described. This is the most painful experience I’ve ever had. I’m using Vaseline, aquafor, vitamin E and icing to help with the pain - but it is so draining to be in pain all day long and constantly applying ointments. At what point did you feel like your lips were starting to heal? I don’t think my lips are getting any worse but I don’t feel like they are getting any better either. Just looking for an approximate light at the end of this dark tunnel. And I’m going to buy an aloe plant tomorrow!

RE: using fluorouracil 5% cream on lips

by jayjay43 on Wed Aug 29, 2018 06:23 PM

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Jlynnr, I used Bag Balm. Has all the benefits of Vaseline, plus other healing properties. Worked great! I put it on before bed. You can buy it at hardware stores or grocery stores.

RE: using fluorouracil 5% cream on lips

by zipper2544 on Thu Aug 30, 2018 03:08 PM

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Hi Jlynnr, I only have 2 more nights and I'm finished.  It took into the third week before I saw AND FELT a difference in my lips.  they are still dry and a wee bit cracked but no bleeding.  I only applied vaseline, as that was all my Doc wanted me to use.  Maybe check with your Doc and see if he/she recommends anything else.  Hold tight, the end comes sooner than you think!! 

RE: using fluorouracil 5% cream on lips

by CharlesD on Thu Feb 20, 2020 10:57 PM

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Zipper, were you advised to use fluorouracil 5% only at night, that is, one time a day, or was the prescription for twice a day? After reading the comments on the board, I am very leery about using the cream twice a day. Since quite a bit of time has passed since your post, how have things turned out? I am pissed about the lack of instructions given by the doctor, especially when putting fluorouracil on the lips, the entrance to the mouth. How do you drink, eat, brush teeth, wash face without ingesting or accidently removing cream?

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