Glioblastoma - IDH wildtype; MGMT unmethylated

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Glioblastoma - IDH wildtype; MGMT unmethylated

by dbkat on Tue Jun 12, 2018 10:08 PM

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Anyone know anyone doing well under any clinical trials with a similar genomic profile? The options seem a lot more limited since chemoradiation does not seem to help much in this case.

My sister was diagnosed with GBM in July 2017. We just found out there's recurrence last week. She was in the lapatinib clinical trial since she has EGFRvIII amplification. (chemoradiation + lapatinib) Any input or information would be appreciated!!

RE: Glioblastoma - IDH wildtype; MGMT unmethylated

by thedayna1 on Wed Jun 20, 2018 03:41 PM

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hi!  try the tocagen trial at vanderbuilt university.  its a 50 50 shot of getting it. but it wecomes people with those genetic markers and a lot of trials dont.   we did not get the virus. after surgery but its a coin toss if you do.  xx

RE: Glioblastoma - IDH wildtype; MGMT unmethylated

by MommaCat on Thu Jun 21, 2018 02:28 PM

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On Jun 12, 2018 10:08 PM dbkat wrote:

Anyone know anyone doing well under any clinical trials with a similar genomic profile? The options seem a lot more limited since chemoradiation does not seem to help much in this case.

My sister was diagnosed with GBM in July 2017. We just found out there's recurrence last week. She was in the lapatinib clinical trial since she has EGFRvIII amplification. (chemoradiation + lapatinib) Any input or information would be appreciated!!

My wife has the precise profile of gene expression you indicated your sister presents.  We've been back-and-forth between VICC at Vanderbilt and PRTBTC at Duke for the past eight months.

You should look into Duke's D2C7 bacteria-based immunology (Pseudomonas aruginosa) that's still in Phase I Open Label design.

RE: Glioblastoma - IDH wildtype; MGMT unmethylated

by dbkat on Thu Jun 21, 2018 05:08 PM

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On Jun 20, 2018 3:41 PM thedayna1 wrote:

hi!  try the tocagen trial at vanderbuilt university.  its a 50 50 shot of getting it. but it wecomes people with those genetic markers and a lot of trials dont.   we did not get the virus. after surgery but its a coin toss if you do.  xx

Thanks for the response! We're considering that trial as a backup right now. Best wishes to you and and your loved one.

RE: Glioblastoma - IDH wildtype; MGMT unmethylated

by dbkat on Thu Jun 21, 2018 05:13 PM

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On Jun 21, 2018 2:28 PM MommaCat wrote:

On Jun 12, 2018 10:08 PM dbkat wrote:

Anyone know anyone doing well under any clinical trials with a similar genomic profile? The options seem a lot more limited since chemoradiation does not seem to help much in this case.

My sister was diagnosed with GBM in July 2017. We just found out there's recurrence last week. She was in the lapatinib clinical trial since she has EGFRvIII amplification. (chemoradiation + lapatinib) Any input or information would be appreciated!!

My wife has the precise profile of gene expression you indicated your sister presents.  We've been back-and-forth between VICC at Vanderbilt and PRTBTC at Duke for the past eight months.

You should look into Duke's D2C7 bacteria-based immunology (Pseudomonas aruginosa) that's still in Phase I Open Label design.

Could I ask if your wife is currently on this trial? And if so, how is she doing on it? I'm not familiar with it, but will definitely look into it. Not having the favorable prognostic markers makes clinical trial searching more difficult and feels like such a bigger mountain to climb. Thanks for the response. It's much appreciated.

RE: Glioblastoma - IDH wildtype; MGMT unmethylated

by MommaCat on Fri Jun 22, 2018 02:30 PM

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