Xofigo (radium 223) ?

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Xofigo (radium 223) ?

by OMB02 on Wed Jun 13, 2018 06:41 PM

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Is there anyone who is getting or has gotten Xofigo (radium 223) willing to share their experience with it ?

RE: Xofigo (radium 223) ?

by genemyers on Sun Jun 17, 2018 06:17 AM

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I have not had this treatment but from what I hear it is extremely well tolerated, given 6 infusions once a month for 6 months.  The treatment takes about 20 minutes to perform.  It only works on the bone.

They are currently doing clinical trials to see if patients can get a second round of 6 month treatments. 

In the clinical trial that approved this drug, some patients had a complete disappearance of cancer on their bone scans.

Best of Luck,

Gene

RE: Xofigo (radium 223) ?

by genemyers on Sun Jun 17, 2018 06:54 AM

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Most doctors time Radium so that you have a fair amount of bone mets before you get it.  The reason is that it only works on the bone mets and you currently can only get a round of Radium once, by 6 monthly injections.

Radium 223 has been in use for 6 years.

You can have Radium and then go on chemo, no problem as long as you are a candidate for chemo (called performance status).

An issue may occur due to a possible minimal myelosuppression (low blood cell counts) of the bone marrow from Radium, that if you were to go right onto chemo, the chemo might make it worse.  They might have to wait a little bit after Radium for you blood counts to normalize over time, which they normally do.

You can get drugs or a transfusion or wait for a while to reverse myelosuppression, but this is an issue that you should throughly discuss with your doctor so that you know what the plan is, if you are thinking of doing Radium and then Taxotere.

Best wishes,

Gene

RE: Xofigo (radium 223) ?

by OMB02 on Mon Jun 18, 2018 06:31 PM

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On Jun 17, 2018 6:54 AM genemyers wrote:

Most doctors time Radium so that you have a fair amount of bone mets before you get it.  The reason is that it only works on the bone mets and you currently can only get a round of Radium once, by 6 monthly injections.

Radium 223 has been in use for 6 years.

You can have Radium and then go on chemo, no problem as long as you are a candidate for chemo (called performance status).

An issue may occur due to a possible minimal myelosuppression (low blood cell counts) of the bone marrow from Radium, that if you were to go right onto chemo, the chemo might make it worse.  They might have to wait a little bit after Radium for you blood counts to normalize over time, which they normally do.

You can get drugs or a transfusion or wait for a while to reverse myelosuppression, but this is an issue that you should throughly discuss with your doctor so that you know what the plan is, if you are thinking of doing Radium and then Taxotere.

Best wishes,

Gene

Thank you Gene for the good info about radium 223. Greatly appreciated!

Take Care,

Monty

RE: Xofigo (radium 223) ?

by OMB02 on Wed Aug 01, 2018 06:04 PM

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On Jun 17, 2018 6:54 AM genemyers wrote:

Most doctors time Radium so that you have a fair amount of bone mets before you get it.  The reason is that it only works on the bone mets and you currently can only get a round of Radium once, by 6 monthly injections.

Radium 223 has been in use for 6 years.

You can have Radium and then go on chemo, no problem as long as you are a candidate for chemo (called performance status).

An issue may occur due to a possible minimal myelosuppression (low blood cell counts) of the bone marrow from Radium, that if you were to go right onto chemo, the chemo might make it worse.  They might have to wait a little bit after Radium for you blood counts to normalize over time, which they normally do.

You can get drugs or a transfusion or wait for a while to reverse myelosuppression, but this is an issue that you should throughly discuss with your doctor so that you know what the plan is, if you are thinking of doing Radium and then Taxotere.

Best wishes,

Gene

Hello Gene,

Do you know if would be normal for Radium 223 treatment to result in a lowering of one's PSA ?

I was of the opinion, maybe mistaken, that Radium 223 would not be expected to lower one's PSA.

Prior to my second treatment, something stopped my PSA from rising and lowered it also (slightly).

I'm not sure whether to attribute it to the Radium or something else.

Take Care,

Monty

RE: Xofigo (radium 223) ?

by genemyers on Sat Aug 04, 2018 04:34 AM

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I think it is the general concensus that Xofigo does not reliably reduce psa and you can have a good response without the psa going down. 

Some patients do have a lowering of psa, but this is not required for the drug to be working.  I think a lower psa is viewed as an added bonus.  If your psa has been lowered it is probably the Xofigo.  Also, If your psa starts to rise that does not mean the Xofigo is not working. 

When you have bone mets, psa is not the end all beat all test.  The proof is in sucessive scans where they compare a scan after treatment to the prior scan and can see lesions disappearing due to the treatment.

Best wishes

Gene

RE: Xofigo (radium 223) ?

by gpgpgp on Sat Aug 11, 2018 07:48 AM

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In Europe there is a warning to use Xofigo:

http://cancerology.blogspot.com/2018/07/restriction-of-xofig

RE: Xofigo (radium 223) ?

by gpgpgp on Sat Aug 11, 2018 07:54 AM

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This doctor made a good presentation for Xofigo at a prostate cancer conference just before the warning was published:

http://videolibrary-mirrorsmed.s3.amazonaws.com/prosca13/THM

You may want to watch it to learn about Xofigo.

RE: Xofigo (radium 223) ?

by OMB02 on Sun Oct 07, 2018 01:38 AM

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Just an update...

I guess I'm one of the unlucky ones that it does not help. I did lose 9 pounds, though, without trying.

Had three rounds of Xofigo. My ALP lowered with each round...with the most recent count being 105. After my third round, a bone scan showed that new bone mets had developed, so my Xofigo was stopped after three rounds. I was sure that it would put a halt on my bone mets, but I was wrong.

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