stage 3 kidney cancer and treatment

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stage 3 kidney cancer and treatment

by tcain on Mon Jun 17, 2019 03:13 PM

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Any one having or had stage 3. kidney and renal vein removed. now on to sulent

RE: stage 3 kidney cancer and treatment

by tomretired on Thu Jun 20, 2019 06:55 PM

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I was diagnosed stage 4 RCC 1/18. I had my kidney and adrenal gland removed, started on Sutent in April for one year. 50 mg once a day. Fourteen days on seven off. There were some side effects most could be controlled with OTC stuff. Sutent did raise my blood pressure so I was prescribed meds which controlled it.

RE: stage 3 kidney cancer and treatment

by CELINEngss on Fri Jun 21, 2019 05:18 AM

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I would like to share this good news.

My friend has 4th stage renal cells carinoma kidney cancer mets to the lung. One of ther kidney was removed.  Onco said chemo will not respond in her case.

Instead, started her on immunotherapy (ippilimumab and nivolumab).  After a few cycles, the cancer nodules on the lung which is near to the heart, disappeared.  The other small nodules at the side of the lungs were surgically removed.  Now her onco declared her as cure!  Ask your dr about immunotherapy treatment.

RE: stage 3 kidney cancer and treatment

by mamacita3748 on Mon Sep 02, 2019 04:47 PM

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On Jun 17, 2019 3:13 PM tcain wrote:

Any one having or had stage 3. kidney and renal vein removed. now on to sulent

So sorry to hear what you're going thru tcain.  I find myself in the same difficult boat.  I was diagnosed on 6/26, full left nephrectomy on 7/22.  The pathology lab report after surgery upstaged my 5 cm clear cell tumor to stage pT3a based on two factors that make these tumors more aggressive - renal vein invasion and WHO/ISUP cell differentiation Grade 3.

My onc has scheduled me to start on Sutent to try to prevent metastasis for Wed Sept 4 of this week (2 days hence) on a 2 weeks on, 1 week off cycle to try to reduce the really serious side effects of this drug.  

I'm worried about how it will go and would love to hear about your experience, if you feel like sharing.  I plan to return to post my experience here once I start on the drug in the hope it will help others.  Again, so sorry you're going through this and hope you have loved ones around you to help.

RE: stage 3 kidney cancer and treatment

by mamacita3748 on Mon Sep 02, 2019 04:58 PM

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On Jun 17, 2019 3:13 PM tcain wrote:

Any one having or had stage 3. kidney and renal vein removed. now on to sulent

Another very real concern is the unbelievable cost of this med.  Really, Pfizer should be taken out and hung from the nearest tree as a highwayman.  I am currently on my husband's insurance from work and, since we've met all our annual out-of-pocket spending limits (for the first time ever, LOL), our copays for Sutent are $0.  The problem is that I'm aging into Medicare in November which is a whole different beast.  I checked every insurance company authorized to sell Medicare Gap insurance in Texas and their copays run from $5000 to $20000. PER 3 WEEK CYCLE.

Even tho' my sweet brother offered to buy a cycle, it looks like we'll only be able to cover the cost into December before the piggy bank runs dry.  I see my onc tomorrow and will ask if it's even worth it to start the med knowing we won't be able to afford 4 months, much less the year she wants me to take it.  <sigh>

RE: stage 3 kidney cancer and treatment

by mamacita3748 on Mon Sep 02, 2019 06:02 PM

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Aside from the toxicity and cost of Sutent, I'm also concerned that the evidence that it is even effective is so very very weak.  Regardless, my husband and I have decided to proceed for as long as we can, given that there is absolutely no other alternative.

These are 4 URL's  you can use to read the few studies/analyses that have been published with, sady, conflicting results.  Hope it helps:

1.  Sutent (sunitinib) delayed the time to cancer return than a sugar pill, but not at a statistically significant level

S-TRAC STUDY (Pfizer sponsored)

From Summary of New England Journal of Medicine, Dec 8 2016

Adjuvant Sunitinib in High-Risk Renal-Cell Carcinoma after Nephrectomy (Ravaud, A. et al)https://www.ncbi.nlm.nih.gov/pubmed/27718781

2.  The sugar pill did a better job at delaying cancer return than Sutent

ASSURE Trial

From May 2016 (Haas, Naomi B. et al)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878938/

3.  The authors of the ASSURE Trial ran a separate analysis looking only at higher risk subjects and the sugar pill still did better than Sutent

UPDATE  to ASSURE Trial

From Sep 2017

Adjuvant Treatment for High-Risk Clear Cell Renal Cancer

Updated Results of a High-Risk Subset of the ASSURE Randomized Trial

https://jamanetwork.com/journals/jamaoncology/fullarticle/26

4.  A meta-analysis was done on combined data from the S-TRAC and ASSURE trials and the sugar pill did better

From Annals of Oncology, April 2017

Adjuvant sunitinib for high-risk-resected renal cell carcinoma: a meta-analysis of ASSURE and S-TRAC trials

B.Gyawal i, Y. Ando

https://academic.oup.com/annonc/article/28/4/898/2716544

RE: stage 3 kidney cancer and treatment

by sagarshrma on Sat Oct 05, 2019 11:19 AM

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On Jun 17, 2019 3:13 PM tcain wrote:

Any one having or had stage 3. kidney and renal vein removed. now on to sulent

Dear Tcain

Sorry to hear about your diagnosis to kidney cancer . My dad was diagnosed with stage 4 , 2 years back . He started sutent immediaely and he is responsding well to the medication . His tumors have shrunk significantly . Only problem is that the side effects become extreme near the end of the cycle .

The medication for kidney cancer has advanced a lot and there are so many new options like immunotherapy . Stay strong .. 

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