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Kidney Cancer:avastin and Tarceva

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Kidney Cancer:avastin and Tarceva

by Jbroder2000 on Sat Apr 09, 2005 12:00 AM

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I have stage 4 renal cell cancer..kidney removed exactly 2 yrs ago, found spots on my lungs on the novemeber scan which had grown. pulmonectomy done last Dec. diagnosis: metatastaic renal cell (in the lungs). I tried interferon with little results. My oncologist doesn't like the side effects of interluken. Most of her patients had to be hospitalized for the side effects. The new Avastin/tarceva is not approved for renal cell, but I see it has had good results. My insurance won't cover either. But I'm starting the Avastin Monday and hope to start the Tarceva soon. On Oxygen, 3 liters. Any suggestions? thanks.

Response to Joseph b, Kidney Ca.

by Sheree on Tue Apr 12, 2005 12:00 AM

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Hi Joseph: I am about two years out with the same, stage IV kidney cancer, which has mets to the chest wall and lungs also. I was lucky enough to have an oncologist in Maine who had connections with the Beth Israel Deaconess Medical Center in Boston, MASS, and was referred there at the first sign of a node in the chest wall July 2004. I was healthy enough and 48 years old to be accepted in a clinical trial for the Avastin /Tarceva, double blinded study to study the effects of Tarceva or the placebo with the Avastin. I had severe acne type rash, so the doctors assumed I was on the Tarceva and not the placebo. The meds worked a bit for a little while, and after 7 months, a new node appeared in the right chest area somewhere. It is in the lymph system. So they now have a new trial starting with a drug by Pfizer, Phase II, called SU11284, and the doc calls it SUgen. It is in the Pfizer web site under new drugs. It is a clinical trial which I will start tomorrow. This is in pill form. I am anxious to see how it works. The docs are hopeful in that they are told it will be far superior to the Avastin. These are angiogenesis drugs, as you know , which affect the VEGF growth factor of tumors. Please let me know where you live, and are you being treated at a Cancer Center, or is there one near you? One man I have seen in Boston drives up from Conneticut. He is only 43 or so, wwith 3 small kids too, and he is on the Avastin. They study they are in just got extended for another year, so that is good news. It just didn't seem to work that well for me. I am not on oxygen or anything. I am working and felling okay, other than worries and stress. We have one son, graduating high school this spring and I am working on his college financial planning. This is what keeps me busy and going. Please write back if you wish and we can be support to each other. Sheree

Kidney Cancer,avastin

by Ozge_g on Mon Apr 25, 2005 12:00 AM

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Hi Sheree My mother has stage IV kidney cancer which has mets to the lung,liver,lymph nodes.She start avastin,inerferon and interluken 2 months ago.before this,she used interferon and xeloda.(but its side effect was terrible).2 days ago we learn that it mets to her bones.When I read yor mesagge,I want to ask you about Pfizer,SUgen.I heard this drug for the first time.and I'm thinking of mention this drug to the doctor. I can say that I feel incurable sometimes.my mother has so much pain. thanks

Rcc

by Sheree on Tue Apr 26, 2005 12:00 AM

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Hello.I am 49 years old and just started the Pfizer /SU011824 (Sugen). It is a phase II clnical trial out of Dana Farber Harvard cancer center in Boston. I was selected as their first person to use this drug for RCC at that facility. The side effects are just starting. I am in Florida visiting family and having a lot of back pain, or gas pain, low back, which migrates to sides and tummy and pelvic area. I would say it was the new drug. Can't do a lot of eating, as I would like to. I think if you go on the National Cancer Institute web site and then to new drugs, then Pfizer to look it up. I don't have a lot of information on it. It is similar to avastin and works in the same way but it also targets 6 other things in the tumor. It does cause high blood pressure for one thing, I know like the Avastin. I did well on the Avastin/tarceva double blinded study for 7 months, it kept things stable, then I grew new nodes in the chest wall, lymph system. It has not reached my other organs, or bones, or brain. I am hopeful this is the one, and then there is a new drug coming out by Bayer soon, not sure of the number or name of it yet, But now the drug companies are all pushing their research for new drugs.I really do not want to do the interferon or interluken, but of course, if I have to I will. I still work part time, and maintain my family and house hold. I have a husband and a son who is a senior in high school. Sheree

Avistin and Tarceva

by Jer316 on Sun May 08, 2005 12:00 AM

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I just started avistin and tarceva 2 weeks ago and just broke out with a severe rash on my face and neck. Was there anything they did to lessen the side effect or is it something you just have to live with. I would like to continue this treatment. Please let me know if they did anything for you and how you responded.

Same Boat Know The Feeling

by Stageiv on Tue May 17, 2005 12:00 AM

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To Joseph B: I also have stage IV with multiple spots the largest is starting to rub here and there. I recently started on avastin/tarceva after other treaments went bust. My local Onc is pretty good,and recommended this treatment off the bat when he delivered the news of my latest growth. Started on 150mg but rash was to severe, now on 100mg we will see what happens. If you need support let me know.

Stage iv Also

by Stageiv on Tue May 17, 2005 12:00 AM

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Sheree I also have stage IV with 20 + spots in different lung areas. Also had a kidney removed when cancer was first found. I did my trials IL2/IL12 and anti - CTLA4 and NIH. Although the treatments were unsuccessful they did help others. I am in the medical field as are many in my family, and I can commend them for their high level of expertise and care. I am sure that you probably had similar experiences in Boston. If you are like me support from others in similar situations can be helpful. You are right aout the new drugs coming out like SUgen. Pfizer is also testing another new one (AG-013736). According to the various releases, studies have shown promising results. If you feel like chatting let me know Stage IV (TJ)

Tarceva Rash

by Jbroder2000 on Tue May 17, 2005 12:00 AM

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Hi, From the suggestion of a member of the cancerguide list, I tried the prescription metrogel. Seems to take away the itch. Also another suggestion there was Tree Tea Oil Spray which I found at a health food store. Works well also and then for a lotion, Avon Skin So Soft helps some too. Good luck, Joe

Know The Feeling

by Jbroder2000 on Tue May 17, 2005 12:00 AM

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Hi. I'm just about a month into the Avastin/Tarceva treatment. My Dr put me on 100 mg to start with...so far the rash has been manageable, but a nuisence. No diarrhea to speak of, just 2 episodes and a dose of ammodium put it in check. Have my first CT scans May 31. Good luck to you. Joe.

Tarceva Rash

by Sheree on Tue May 17, 2005 12:00 AM

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Hi, I had severe case of acne bumps, pus and bloody on my face and for a while I went down to the next dose, but they had me on Keflex 500 mg. for a week and then off for a week. At one point, I had to be on prednisone for a few days to calm it down. The rash on the chest and back were not that itchy, but did burn some. The face was my worst. Then also had given me clindamycin topical to use. Good luck with it. I am now on Sugen and I have had 25 to 30% shrinkage of a good portion of my lymph nodes with the others remaining stable after only 3 weeks of the pills. Yeah, I think this is going to put me in remission. I am so thankful. Praise the Lord.
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