5fu Toxic/deadly if You Have Dpd Enzyme Deficiency

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RE: 5fu Toxicity

by Geneguy on Tue Dec 12, 2006 12:00 AM

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Molecular Diagnostics Laboratories in Cincinnati, OH tests for DPD enzyme deficiency.  mdl-labs.com  Hope this helps.

RE: 5fu Toxicity

by Np2000 on Sat Dec 16, 2006 12:00 AM

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I am totally horrified ready comments on this thread. My wife is going to have chemo with 5-FU in it. Should I contact the onc and ask him to allow her to check for DPD deficiency? or do you do the checking on your own?

RE: 5fu Toxicity

by Geneguy on Sat Dec 16, 2006 12:00 AM

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On 12/16/2006 Np2000 wrote:

I am totally horrified ready comments on this thread. My wife is going to have chemo with 5-FU in it. Should I contact the onc and ask him to allow her to check for DPD deficiency? or do you do the checking on your own?
You can do it either way but I would suggest going through the onc doc and having him/her included in everything, especially for when the results come back so you can get a good interpretation.  The test is covered by insurance and should be done on anyone prior to administration of 5-FU or any 5-FU cream.  Somewhere around 3-5% of people will have an adverse reaction (toxicity) to 5-FU.  This is high enough to not take a gamble on.  Good luck to you and your wife.

 

RE: 5fu Toxicity

by Np2000 on Sun Dec 17, 2006 12:00 AM

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On 12/16/2006 Geneguy wrote:

 

You can do it either way but I would suggest going through the onc doc and having him/her included in everything, especially for when the results come back so you can get a good interpretation.  The test is covered by insurance and should be done on anyone prior to administration of 5-FU or any 5-FU cream.  Somewhere around 3-5% of people will have an adverse reaction (toxicity) to 5-FU.  This is high enough to not take a gamble on.  Good luck to you and your wife.

 

I will contact the doctor's office first thing tomorrow. I am just surprised that they diddnt tell us anything about this during our "teaching" session.

 

Thank you

 

RE: 5fu Toxicity

by Np2000 on Mon Dec 18, 2006 12:00 AM

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I called the nurse today and they have her scheduled for a test tomorrow. They did admit that this is a dangerous risk, but it is not standard testing.

thanks for the posting...

RE: 5fu Toxic/deadly if You Have Dpd Enzyme Deficiency

by Luckyj on Sun Jan 14, 2007 12:00 AM

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I am so grateful to learn of this message board and to find that others have had problems with 5fu.  I do not have cancer, but  be aware that 5fu is being used to treat problems other than cancer.  I have pigmentary glaucoma, and have had 2 separate implants put into my eye to relieve the ocular pressure.  Both implants have had problems to develop when they became clogged with eye pigments.  In order to save the most recent implant 5fu was injected into my eye to thin the secretions and allow the fluid to be released.  5fu was successful in lowering the pressure in my eye and saving the implant (for the time being), but 7 days after this injection of 5fu, I became very ill with severe diarrhea, then severe nausea and finally also a change in my taste perception.  Now, 6 weeks later (and 20 pounds lighter) I am much better, though my taste perception is still "off".  I have never had problems like this before.  I've had a few stomach viruses in my 68 years, but generally I have a very "strong stomach".  I do not want to risk using 5fu again should the implant (called a "bleb") clog up again in my eye.  Thank you for alerting me to the possibility that I may be in the group of those with a DPD deficiency!

RE: 5fu Toxicity

by hamburger on Thu Aug 16, 2007 12:00 AM

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Could you tell me how long this test has been available?

RE: 5fu Toxic/deadly if You Have Dpd Enzyme Deficiency

by hamburger on Thu Aug 16, 2007 12:00 AM

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My wife had a similar reaction to 5FU.  She did survive but does have a slight memory deficit.  We were told the same story re. the enzyme deficiency and that testing was not part of the standard of care

She spent 6 weeks in a Boston Hospital, one of those weeks was in the ICU.  She suffered a pneumothorax due to a TPN line needed to feed her.

I was also told that we might loose her but luck was with us and we did'nt.

The cost of the test is minimal.  Both your hosptalization and my wife's hospitalization costs were astronomical. Every one considering 5FU should be tested as part of the chemotherapy protocal.

I'm happy that things turfned out well for you.

RE: 5fu Toxic/deadly if You Have Dpd Enzyme Deficiency

by Snowmom60 on Thu Aug 16, 2007 12:00 AM

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Now that you have all scared the you know what out of me, were any of you/loved one on continuous infusion 5FU?  I'm on day 11, would I have already gotten the reaction?

Thanks,

Terry

RE: 5fu Toxicity

by Geneguy on Thu Aug 16, 2007 12:00 AM

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On 8/16/2007 hamburger wrote:

Could you tell me how long this test has been available?

The test has been available since 1998.

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