5fu Toxic/deadly if You Have Dpd Enzyme Deficiency

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RE: 5fu Toxic/deadly if You Have Dpd Enzyme Deficiency

by DaveBartholomew on Thu Feb 26, 2015 11:42 PM

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Although what?  Please!  Do not repeat propaganda.  Anyone making millions of dollars off such a destructive drug, "Will continue to publicise that THE DRUG IS VERY EFFECTIVE"   (below)

         Sorry.  I'm just a bit emotional about it, for it has caused me to be very sick, near death. 

      quote:   " 5-fluorouracil (5-FU) is a chemotherapy drug used to treatseveral types of cancer, including colorectal, breast, esophagealand stomach.  Although the drug is very effective, there is adownside: about 30% of people receiving this therapy sufferfrom serious and sometimes deadly toxicity.

         Sorry.  I'm for children speaking up for their mom.  You have experience. You communicate well.  Please demand that you share the resolving treatment plan.

Second.  The more I speak with Oncologists, the more I see the dollar sign, the the 'caution sign'.

Cancer spreads for many reasons, but one huge reason often ignored is the Immune System is very weak and can't fight off the spreading disease.  What if you super charged the immune system to enable capabilities it had as youngster.  

What if you go in cut out everything?  Do transplants with a supercharged immune system (like HIV new drugs?)

Summary:  When Chemo doctors tell you there will be horrible side effects, you are lucky for most don't tell you.  Instead, they say 'the vitim may die soon is nothing is done'. I say, "BS - I heard that one berfore."

5FU is much worse than reports tell you.  Thank you Cancer Compass for being here for the victims of 'harmful doctors'.

Sincerely yours,  Dave B.   Dana Point, CA

sebastopoljohn sebastopoljohn
(Inactive)

RE: 5fu Toxic/deadly if You Have Dpd Enzyme Deficiency

by sebastopoljohn on Fri Feb 27, 2015 02:16 AM

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On Feb 26, 2015 11:42 PM DaveBartholomew wrote:

Although what?  Please!  Do not repeat propaganda.  Anyone making millions of dollars off such a destructive drug, "Will continue to publicise that THE DRUG IS VERY EFFECTIVE"   (below)

         Sorry.  I'm just a bit emotional about it, for it has caused me to be very sick, near death. 

      quote:   " 5-fluorouracil (5-FU) is a chemotherapy drug used to treatseveral types of cancer, including colorectal, breast, esophagealand stomach.  Although the drug is very effective, there is adownside: about 30% of people receiving this therapy sufferfrom serious and sometimes deadly toxicity.

         Sorry.  I'm for children speaking up for their mom.  You have experience. You communicate well.  Please demand that you share the resolving treatment plan.

Second.  The more I speak with Oncologists, the more I see the dollar sign, the the 'caution sign'.

Cancer spreads for many reasons, but one huge reason often ignored is the Immune System is very weak and can't fight off the spreading disease.  What if you super charged the immune system to enable capabilities it had as youngster.  

What if you go in cut out everything?  Do transplants with a supercharged immune system (like HIV new drugs?)

Summary:  When Chemo doctors tell you there will be horrible side effects, you are lucky for most don't tell you.  Instead, they say 'the vitim may die soon is nothing is done'. I say, "BS - I heard that one berfore."

5FU is much worse than reports tell you.  Thank you Cancer Compass for being here for the victims of 'harmful doctors'.

Sincerely yours,  Dave B.   Dana Point, CA

You are correct when you say that 5-FU can be deadly. I, too, could easily have died because of DPD enzyme deficiency and 5-FU, but I don't think your numbers are quite right. It is my understanding that only 8% of people, at most, have the deficency to some degree. Those whose immune system is temporarily destroyed have a 30% chance of dying from it, hence, with no prior testing for the deficency, a maximum of 2.4% of FOLFOX recipients will perish from it. Even that is unacceptable, though, given that with a simple test, such deaths can be avoided.

RE: 5fu Toxic/deadly if You Have Dpd Enzyme Deficiency

by DaveBartholomew on Sat Feb 28, 2015 12:05 AM

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Dear (John) sebastopoljohnon Fri Feb 27, 2015 02:16 AM

Don't do it. Don't promote those numbers as I have experienced that these numbers are upside down.  I talked a person who was a expert witness when this 2004 presentation was before the U.S. Congress, the FDA, and I don't see the support.  The charts that I saw, showed only a 5% to 8% increase chance that health would improve.  This is such a slight number and the risk is far to great.   To me, the comparison is closer to 80% of people will be worse than when they started.  15% might stay the same or is in long term immune slide.  Or, 5% of people get better because of the related treatment, while at the same time using 5FU.  My understanding is the tests were not conducted except with support (radiation, or support of other meds in conjunction.) 

Remember the movie, 'The Fugitive'.   Well same thing here.

Dave.   PS.   Don't be a mouth piece for this horrible pretender 5FU.

sebastopoljohn sebastopoljohn
(Inactive)

RE: 5fu Toxic/deadly if You Have Dpd Enzyme Deficiency

by sebastopoljohn on Sat Feb 28, 2015 01:41 AM

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On Feb 28, 2015 12:05 AM DaveBartholomew wrote:

Dear (John) sebastopoljohnon Fri Feb 27, 2015 02:16 AM

Don't do it. Don't promote those numbers as I have experienced that these numbers are upside down.  I talked a person who was a expert witness when this 2004 presentation was before the U.S. Congress, the FDA, and I don't see the support.  The charts that I saw, showed only a 5% to 8% increase chance that health would improve.  This is such a slight number and the risk is far to great.   To me, the comparison is closer to 80% of people will be worse than when they started.  15% might stay the same or is in long term immune slide.  Or, 5% of people get better because of the related treatment, while at the same time using 5FU.  My understanding is the tests were not conducted except with support (radiation, or support of other meds in conjunction.) 

Remember the movie, 'The Fugitive'.   Well same thing here.

Dave.   PS.   Don't be a mouth piece for this horrible pretender 5FU.

Hey Dave,

My case is just one in who knows how many, and I won't say all cases are going to be like mine, BUT when my colon cancer was found, it was very large, blocking 60% of my colon. My gastroenterologist marked the extents of the tumor with tatoos, the better to acess the progress later on. After five weeks of being on a 5-FU pump for five days a week, and simultaneously getting radiation treatments, also five days a week for five weeks, all that my colorectal surgeon could see in between the tatoo marks was scar tissue, not cancer. I went ahead with surgery anyway, for fear there was still some cancer he couldn't see. For me the initial treatment was very successful, and it wasn't until the heavier dosages of the FOLFOX regimen after surgery that I had a very severe reaction. Now if you have verifiable data that 5-FU is as useless as you say, please post your sources so that folks with cancer can make up their own minds, otherwise, as a person who has both benefitted ans suffered terribly from the use of 5-FU, I will continue to recommend that:

1) people slated for 5-FU infusions get a DPD enzyme deficiency test! Don't start the infusions until the results are in!, and

2) If you do produce sufficient DPD enzyme to metabolize the 5-FU, make up your own mind, based on the evidence, as to whether or not you want the drug.

I advise that you do have the treatment if you can, and Dave advises that you don't, no matter what, but neither of us are experts in oncology. Base your decision on the findings of the folks who are experts.

I would not want to be Dave if someone took his advice at face value, refused 5-FU treatment, and then it could be conclusivly shown that they died as a result.

May you all be cancer-free, John

RE: 5fu Toxic/deadly if You Have Dpd Enzyme Deficiency

by DaveBartholomew on Sun Mar 01, 2015 12:33 AM

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(John comments in ital: )   J:   For me the initial treatment was very successful, and it wasn't until the heavier dosages of the FOLFOX regimen after surgery that I had a very severe reaction.

Dave reply:    Congrats on your initial results (BUT):  I too had cancer, anal cancer small tumor, with (guestimate, other than a flare on a CT/PET scan that I also had Lypmh node cancer)  Not verification of that (BUT) they sure used the unverified 'flare' to scare me, as in "This is a last resort treatment - 5FU is the last resort."  Nothing was true.  I had a anal-polyp that is typical spreading of disease from a Black Widow bite Oct. 2008 - envenomization with very weak Immune System.  Dec. 2009 5FU Cath-Pump, 5 days.  2014 biopsy of small spreading venom polyp with 'carcenigenic componentes / non-squamous region.   I have had multiple haeart attack since the 5FU Pump 4 inches from heart (2009). 

J:   Now if you have verifiable data that 5-FU is as useless as you say, please post your sources so that folks with cancer can make up their own minds, otherwise, as a person who has both benefitted and suffered terribly from the use of 5-FU, I will continue to recommend that:

D:  I am trying to get sources of the Congressional record!  Maybe we can look at it?  But what makes you believe it is not fabricated after so many people are harmed by it!  Me, you, others.  AND - Radiation may be the sole cause of your recovery for it does kill all the area-cells as you describe.  Point made. 

J:    1) people slated for 5-FU infusions get a DPD enzyme deficiency test!   Don't start the infusions until the results are in!,  and

D:   FIRST -  as per the Dpd Enzyme test:  It is too expensive, about $4,000 out patient expense.  Most people don't have it.

D:   SECOND -  "Don't start ... until"    Until what?  Doctors can scare you, tell you its your last hope; regardless of testing outcomes.  I have venom illness, it is not testable as many disease. ( ie West Nile Virus )

J:     2) If you do produce sufficient DPD enzyme to metabolize the 5-FU, make up your own mind, based on the evidence, as to whether or not you want the drug.

D:    Your doctor makes 10's of thousands on entire treatment.  You have to make up your mind, but doctors are very bias and people die around them all the time, they can build up a callousness - for they have a 'win-win'.  They don't lose making 'scary stories how a patient will suffer'.

J:     I advise that you do have the treatment if you can, and Dave advises that you don't, no matter what, but neither of us are experts in oncology.   Base your decision on the findings of the folks who are experts.

D:    These doctors are not experts on this subject, for they need a crypstal ball to be so.  Why don't you read these blogs John?  And, I don't believe you.  I think you work in the Oncology industry?  Right?

J:      I would not want to be Dave if someone took his advice at face value, refused 5-FU treatment, and then it could be conclusivly shown that they died as a result.

D:    These doctors have many other chemo meds that have proven to have far less destructive and harmful side effects.  Why didn't you say that?  Maybe you are bias and make moeny off the misrepresentations, like the movie 'Fugitive'.

May you all be cancer-free, John

sebastopoljohn sebastopoljohn
(Inactive)

RE: 5fu Toxic/deadly if You Have Dpd Enzyme Deficiency

by sebastopoljohn on Sun Mar 01, 2015 08:32 AM

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OK, no more mr. nice guy. This is my last word on the subject, as I am tired of arguing with you, Dave. Your arguments are not supported by anything more than presumtions, and are irrational in the extreme.

Accusing me of profiting from my stance on 5-FU is underhanded, unfair, and just plain wrong, both ethically and factually. I never have had any financial interests in any part of the medical industry. I am just a retired working stiff. The only thing I have to gain from posting about 5-FU and DPD enzyme deficiency is the satisfaction of knowing that I have done the right thing.

That you are trying to scare people away from a drug that may help to save their lives because of your own experiences and bitterness is flat wrong, and ascribing evil intent to the medical community at large is paranoid and irrational. Doctors are almost never evil, but they are usually very cautious. They want to cover all the bases and give us the best possible care. The only way they can do that is to base treatment plans on statistical evidence relevant to similar cases. In my case, for instance, statistics showed that without FOLFOX, which includes 5-FU, my 5 year survival rate was projected to be 45%, and with it, 65%, so I said to sign me up. It was purely statistical, based on similar cases to mine, but without considering my particlar DPD enzyme status...their only mistake, based on the evidence at hand.

That you call the medical community biased is like the pot calling the kettle black. You hint that because the pump catheter ended near your heart, that 5-FU caused your heart attack...really? Sounds like an unwarrented leap of illogic to me! You also want to compare your unusual "Black Widow" related polyp with possible lymph involvement, with the thousands of folks like myself with big tumors and/or proven lymph involvement, and who need to pull out all the stops and have the cancer aggressively treated. Don't you DARE try to dissuade these people from treatment. You, if you are successful, may be responsible for their deaths!

Also, the price of the DPD enzyme test is not as much as you say. It is now about $75, and could save tens of thousands of dollars, much suffering, and possibly one's life.

5-FU is a toxic substance. I has to be to kill cancer cells. It is simply put, more toxic to cancer cells than it is to normal cells. There will be unpleasant side effects, but that is the price one pays for the increased chance of survival.

I am an old man, way past retirement age, generally not all that well, and I have a degree of DPD enzyme deficiency. I had prostate cancer and colon cancer at the same time. I received high dose rate brachytherapy (radiation) for the prostate, beam radiation to both cancer sites concurrent with 5-FU, had my homones eliminated with Casodex and Lupron (both awful, but effective), and colorectal surgery, and came through all of that feeling crappy, but essentially intact, and it seems to me that, given my age and condition,  if anyone was going to be permanently damaged by it, it would have been me. So don't tell me, or anone else, that 5-FU is necessarily going to damage everyone who is treated with it more than it will help them. It is simply not so. Thousands and thousands of people, young, old, healthy, and ill have been treated with 5-FU and have benefitted from it far more than harmed by it.

RE: 5fu Toxic/deadly if You Have Dpd Enzyme Deficiency

by mcash76 on Sun Mar 01, 2015 09:57 PM

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On Feb 26, 2015 8:56 PM sebastopoljohn wrote:

On Feb 26, 2015 7:20 PM mcash76 wrote:

I am new to this message board, and so glad to have found it. After reading through all of the posts on here I am alarmed the health care profession has done nothing to make the DPD deficiency test a required screening for anyone about to undergo treatment with 5-fu chemo.  

My mom, who is 65 years old, was diagnosed first with stage 4 ovarian cancer in December 2014. She had felt somewhat "constipated" and had a "fullness" in her abdomen since March of 2014 which increased to the point of going to her Internal Med MD.  When they did the Abdominal & Transvaginal Ultrasound they found masses on her uterus, fallopian tubes, and on her omentum (the inner lining of the abdominal cavity), as well as ascites within her pelvis.  She was immediately sent for an Abdominal/Pelvic CT which confirmed the above findings. The IM MD sent her to an Oncoligist who specialized in ovarian cancer.  She performed a vaginal exam in office and discovered there was also colon involvement.  Mom was scheduled for debulking surgery for January 5, 2015.  When they open her up, the cancer was worse than they had anticipated.  It is Signet Ring Cell which is best described as gelatenous.  They were able to do a complete hysterectomy, but were unable to remove any from the colon due to how the tumors were "laying" and "tied into" the actual blood supply of the colon itself.  They were also unable to remove any from the omentum as it was so inmeshed with the normal cell structure, and the largest tumor is on her diaphragm on her left just above her stomach.  They also found a tumor on her appendix, but stated it was too dangerous to take it, or the entire appendix at this time.  The Oncologist spoke with myself and my step-dad after the surgey informing us of her disappointment with the surgery outcome, and her intentions for FOLFOX chemo.  

I am an ICU nurse, and we are trained to think and anticipate what could happen.  My thoughts went immediately the fact that she already had ascites, nausea, vomiting, anorexia related to the abdominal distention, lethargy, and might have weighed 100 lbs prior to the surgery.  During our discussion with the Oncologist, she stated her major disappointment with the surgery was that mom would not really have any relief from the symptoms.  

I then remembered a result from a 23andme DNA test from back when they were still doing the health screenings along with the DNA tests.  When I got a chance, I went into my 23andme account and looked up the results again for my drug response under the Health and Traits section.  Sure enough, there it was...Increased risk for Fluorouracil Toxicity.  I inherited 1 copy of the DPYD*2A mutation, which encodes the DPD enzyme, from 1 of my parents.  

      "Fluorouracil Toxicity

5-fluorouracil (5-FU) is a chemotherapy drug used to treatseveral types of cancer, including colorectal, breast, esophagealand stomach. Although the drug is very effective, there is adownside: about 30% of people receiving this therapy sufferfrom serious and sometimes deadly toxicity. Many cases oftoxicity are due to deficiency of an enzyme called DPD thatnormally breaks down 5-FU in the body. Roughly half of thepeople with DPD deficiency have mutations in the gene thatencodes the enzyme.

Mutations in the DPYD gene, which encodes the DPD enzyme,can cause DPD deficiency. More than 30 mutations in this genehave been reported, although not all of these haveconsequences for 5-FU metabolism. 23andMe reports data forone DPYD mutation in particular, DPYD*2A. About a quarter ofpeople who experience 5-FU toxicity have either one or twocopies of this mutation. Not all 5-FU toxicity is caused by DPDdeficiency, and not all DPD deficiency is due to genetic causes.Other " target="_blank" rel="nofollow">causes.Other " target="_blank" rel="nofollow">causes.Other " target="_blank" rel="nofollow">causes.Other "" target="_blank" rel="nofollow">http://causes.Other " target="_blank" rel="nofollow">causes.Other " target="_blank" rel="nofollow">causes.Other " target="_blank" rel="nofollow">causes.Other " " target="_blank" rel="nofollow">causes.Other " target="_blank" rel="nofollow">causes.Other " target="_blank" rel="nofollow">causes.Other " target="_blank" rel="nofollow">causes.Other "" target="_blank" rel="nofollow">http://causes.Other " target="_blank" rel="nofollow">causes.Other " target="_blank" rel="nofollow">causes.Other " target="_blank" rel="nofollow">causes.Other " " target="_blank" rel="nofollow">causes.Other " target="_blank" rel="nofollow">causes.Other " target="_blank" rel="nofollow">causes.Other " target="_blank" 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(My personal report page at      23andme, 2015)

Not knowing which parent I inherited this from, I of course wanted her tested prior to receiving any chemo.  I said something to the RN she had on her last day in the hospital who relayed the info to one of the residents who stated, "they didn't even know what type of chemo she would be having if any yet", and to "address that during the follow up appointment".  In other words...I don't want to deal with you or your concerns right now.   I decided not to waste my time with said resident, but wait to speak with the Oncologist personally.  

When the path report finally came back, they decided it was Stage 4 appendix cancer with METS, Signet Ring Cell.  So now mom was being sent to another Oncologist who specialized in this type of cancer.  They did an Abdominal CT on January 26th and ended up performing a parcentisis (poked a hold in her abdomen) and drained 1.6 liters of fluid off to try to alleviate her abdominal distention causing her current nausea, vomiting and anorexia.

The next thing I knew, it was February 4th and my mom was texting me telling me she was at the hospital starting chemo.  My heart sank. I live 5 hours from my mom, have a 7 year old daughter, a husband, and work full time also.  I wanted nothing more than to drop everything and be there right then.  The last I had heard they were to start on the 25th, so I thought I still had time.

She went through the initial hospital treatment and was sent home with the port and "bag" for the next 2 days.  She seemed to do ok except for frequent urination, understandably, and extreme weakness. After the treatment was over, she developed severe mucositis with stomatitis (mouth sores), extreme sensitivity to temperatures within her mouth, anorexia of course, and lethargy.  When I brought up the possible deficiency to my step-dad to mention to the Oncologist it was brushed aside and stated that the MD's were doing the best they could for them.  Not being on the list to speak to the MD's/RN's as far as HIPPA goes, I had no where to go.

So mom went in on the 25th for her second round.  Thank the Lord they ran labs before they started the chemo.  She has lost 17 lbs since her last visit, and her white blood cell count went from 10 to 80 (leukocytosis). When I asked what they were planning to do, she said she didn't know yet. She said they had done a chest x-ray, but she still didn't know the results.  So this morning when I called I asked her to please have me added to her list of people who could speak with the MD's and RN's, and also please have them test her for the DPD deficiency.  She then told me they had done the test yesterday when the initial results had come back so elevated, and it will take 2 weeks to result.  She said they were planning on giving her something to try to treat the leukocytosis, but she didn't know what yet.  

So I am back to the waiting game.  I was told by my step-dad recently that the MD's still don't technically know what type of cancer it really is.  From what little I do know about oncology, and the few patients I have had with cancer, it would seem to fall under the category of peritoneal cancer.  I would presume still Stage 4 with METS.  Just wondering what kind of experience anyone else has had with this type. Also, being in the difficult situation of being the daughter when there is a step-parent involved and not wanting to step on toes.  He is a great man, loves her dearly, and takes great care of her, but has the "Let's just all stay positive" mentality.  I'm a very "tell-me-like-it-is" type and want to know what's going on.  Call it the nurse in me or whatever, but this has been one of the hardest parts for me personally.  I just don't want to loose my mom.

Caroline

Do not worry about stepping on toes! Your mom needs an advocate that has the strength to do battle for her. The strength she no longer has.

Some of her symptoms are probably caused by other components of the FOLFOX regimen. Here is what's in the infusions, other than drugs that treat the side effects:

  • FOL–Folinic acid(leucovorin)
  • F –Fluorouracil(5-FU)
  • OX –Oxaliplatin(Eloxatin)

I'm not sure, but I think it is the Oxaliplatin that causes the mouth sores and temperature sensitivity, and I don't know if OX is relevant to the DPD enzyme deficiency problem.

Also, DPD enzyme deficiency manifests in degrees. Your mom may be able to handle some amount of 5-FU, but not the usual FOLFOX dosage. I was able to handle a very slow drip, administered by a portable pump for five days a week, over a five week course, but when I got a full FOLFOX infusion, it completely overwhelmed my immune system. I started running a high fever, and wound up in the hospital where I was given tons of antibiotics and drugs to stimulate my immune system. My white blood count went from 0.3 when I was admitted, which is almost nonexistant, to 11.4 after treatment. In comparison, my white blood count hovered around 3, which is low-normal during the first 5-FU treatment.

So please use the internet to research the heck out of this issue, and when armed with facts and solid references from reputable websites, go do battle for your mom.

Best wishes to you and your mom, John

John, I thank you for you're encouragement and insight.  I have since been able to figure out that mom was admitted with a white blood cell count of 0.78 (normal is 4.80-10.80 per their lab) and neutrophils relative percent of 2 (normal is 45-70% per their lab).  I spoke with my mom the next day on the 27th, who stated they had given her neupogen to treat her neutropenia (decreased neutrophils count) related to the chemo, and antibiotics.  They were giving her morphine to help with her mouth sores which was helping because she had been able to eat 1/2 of a tuna salad sandwhich (which is a big deal for her!), and she was actually resting some.  Plus the morphine was helping with her lung status since it helps to open up the airways.  The then informed me they were talking about running her on chemo within a week or so depending on how her labs looked and if they started to see improvement.  It was then I realized I had to call or do something myself.

I called the MD personally and reached  someone who relayed a message since he was in the clinic that day.  Later I received a call from the Oncology RN.  I told her I knew I was not on the forms to be able to receive info on my mom, but was fully aware of the current situation.  I expressed my concern over the MD wanting to do another round of chemo so soon, especially after still not having the results of the DPD deficiency test beck yet, and relayed the info of my DPD deficiency.  She inquired as to how I had gotten the testing done, and I told her about the 23andme results and how I was not sure which parent it came from, but that it only I had inherited the mutation.  I thanked her for even running the test to begin with.  She stated that with my mom's current state she felt the need to do so, and that in her experience she had only seen 2 cases one of which being my mom's.  She then stated there were other options than the 5-FU and they would check into them.  I'm so glad I called. My mom had tried to tell the MD, but was unable to really say how I had that deficiency or was even tested for it leaving him more confused than anything.

Speaking with my mom today, the MD has now stated they will err on the side of caution, and will continue without the 5-FU at this time until the results are in treating her as though she has the deficiency.  

Mom stated her blood counts are coming up and they are are now playing the numbers game.  She is having trouble with her lung function, but is getting a new pulmnologist , so she is happy about that...as am I.  She told me she even had pancakes and scrambled eggs for breakfast today.  Lord bless her.

So again, I thank you John, for you're encouragement and wisdom you have shared in the hard path you've already tread.

God Bless

Caroline 

RE: 5fu Toxic/deadly if You Have Dpd Enzyme Deficiency

by DaveBartholomew on Mon Mar 02, 2015 12:13 AM

Quote | Reply

John   J:  OK, no more mr. nice guy.

Dave:   I have been in the advertising industry most my life, and your blog sounds like another ad.   If you get your information from the 5-FU web site, don't you think that their ads will be exagerations?  When reading the blogs, I realized that 'paid propagandists' could be participating.  It could be you and your wife pretending to be real patients.  You both write extremely well.  Exactly like the 5-FU web sites.  Therefore, if you don't mind, I hope I am wrong.  I believe there are times to use 'last resort horrible drugs' and yes, if "It gives a very desperate person an increase, long-odds chance, then fine".   5FU is the last resort and people should not be encouraged to use it, Yes, even with all your filtering-hopes that good things will come of it.  Thank you for the good news that the test cost is down to $75.  $3,500 was quoted by my 'good doctor'.  God bless and good life to you.   Dave

RE: 5fu Toxic/deadly if You Have Dpd Enzyme Deficiency

by bamarally on Tue Apr 07, 2015 08:21 PM

Quote | Reply

On Feb 26, 2015 11:42 PM DaveBartholomew wrote:

Although what?  Please!  Do not repeat propaganda.  Anyone making millions of dollars off such a destructive drug, "Will continue to publicise that THE DRUG IS VERY EFFECTIVE"   (below)

         Sorry.  I'm just a bit emotional about it, for it has caused me to be very sick, near death. 

      quote:   " 5-fluorouracil (5-FU) is a chemotherapy drug used to treatseveral types of cancer, including colorectal, breast, esophagealand stomach.  Although the drug is very effective, there is adownside: about 30% of people receiving this therapy sufferfrom serious and sometimes deadly toxicity.

         Sorry.  I'm for children speaking up for their mom.  You have experience. You communicate well.  Please demand that you share the resolving treatment plan.

Second.  The more I speak with Oncologists, the more I see the dollar sign, the the 'caution sign'.

Cancer spreads for many reasons, but one huge reason often ignored is the Immune System is very weak and can't fight off the spreading disease.  What if you super charged the immune system to enable capabilities it had as youngster.  

What if you go in cut out everything?  Do transplants with a supercharged immune system (like HIV new drugs?)

Summary:  When Chemo doctors tell you there will be horrible side effects, you are lucky for most don't tell you.  Instead, they say 'the vitim may die soon is nothing is done'. I say, "BS - I heard that one berfore."

5FU is much worse than reports tell you.  Thank you Cancer Compass for being here for the victims of 'harmful doctors'.

Sincerely yours,  Dave B.   Dana Point, CA

Last November, I took my fiancee to the ER with severe abdominal pain. To make a long story short, they miss diagnosed her ailment. They said gallstones, she had appendicitis. I had to take her back to the ER again that same night. By the time the Dr performed the appendectomy, it had burst, it was cancerous! In January she had a procedure called HIPEC. Heated Intraperitoneal chemotherapy. They also removed some organs that act as sponges for the cancer cells, this was a precautionary.

The surgery went well, but the 5 following days she received 5-fu, she went downhill from there and within 23 days in the hospital, she was gone. She lacked the DPD enzyme that would have let her body metabolize the toxic chemo. Not until AFTER she had received the chemo and her white blood count, and platelets were extremely low, were we told there was a test available to determine the absence if the DPD enzyme! Dr told me it was rare, 1 in a 1,000! THAT IS NOT RARE!  I see on this blog some other people were told the same thing.

I have a question if anyone can help. My fiancee was full Norwegian. Has anyone heard that if people that are Scandinavian, or from northern Europe have a higher degree , genetically, of lacking the DPD enzyme?

RE: 5fu Toxic/deadly if You Have Dpd Enzyme Deficiency

by DaveBartholomew on Wed May 13, 2015 08:20 PM

Quote | Reply

Hello to you Bamarally  in response to your letter 4/ 7/ 15 01:21 PM

The good people at Cancer Compass forward comments to me and all participant writers having first hand experience with 5FU Chemo drug.  Some of us can't sleep thinking about it.

       The ongoing crime of 5FU:  Example misdiagnosis: My life-force was poisoned by venom-DNA toxins in 2007 to 2009 by three insects, Widow spider’08, Recluse spider ‘07, Centipede ’09.

The point being, doctors don’t care about the cause, only how they can ‘Illegally Up-Code’ the seriousness of your condition: (your example).

         Bamarally said: “doctors misdiagnosis: “They said gallstones, she had appendicitis”

Doctors practice.  What a racquet?

I too had appendicitis in 1982,  operation to remove, it was inflamed.   Side note:  (web source:. The following tests are usually used to make the diagnosis:  Abdominal exam to detect inflammation.

Urine test to rule out a urinary tract infection. //  Rectal exam.  // Blood test to see if your body is fighting infection. //  CT scans and/or ultrasound.// a doctor’s experienced touch.

Bamarally said:     “By the time the Dr performed the appendectomy, it had burst, it was cancerous! In January she had a procedure called HIPEC. Heated Intraperitoneal chemotherapy. They also removed some organs that act as sponges for the cancer cells, this was a precautionary.”

              Bamarally said:      The surgery went well, but the 5 following days she received 5-fu, she went downhill from there and within 23 days in the hospital, she was gone

 

              Bamarally said:       "the absence if the DPD enzyme test!   Dr told me it was rare, 1 in a 1,000!    

I disagree Bamarally - as it may be 99 out of 100 people have enzyme imbalance.  Also know, most everyone has had a spider bite, insect bite, centipede bite, etc.  Venom alters the enzyme functioning.

 

              Bamarally said:      THAT IS NOT RARE!    " I see on this blog some other people were told the same thing."  

              Bamarally said:      I have a question if anyone can help. My fiancee was full Norwegian. Has anyone heard that if people that are Scandinavian, or from northern Europe have a higher degree , genetically, of lacking the DPD enzyme?

I have an article about a man returning to the U.S. from France almost died from a tick-bite (envenomation).

           GOOGLE Intraperitoneal hyperthermic chemoperfusion (IPHC) is a type of hyperthermia therapy used in combination with surgery in the treatment of advanced abdominal cancers.[1] In this procedure, warmed anti-cancer drugs are infused and circulated in the peritoneal cavity (abdomen) for a short period of time. The chemotherapeutic agents generally infused during IPHC are mitomycin-C and cisplatin.

         GOOGLE  Cisplatin, cisplatinum, platamin, neoplatin, cismaplat[1] or cis-diamminedichloroplatinum(II)[2] (CDDP) is a chemotherapy drug. It was the first member of a class of platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death).

         GOOGLE   It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.[3]

              Dear Bamarally - you have multiple research opportunities and I hope that you help us to stop this horrible 5FU drug use.      

            Referral to:    The ORGANIZED FIGHT and  web site AGAINST THE 5FU MONEY-CHANGERS:     

             DPD deficiency foundation works towards raising awareness and find a cure from the sufferings of DPD deficient patients. The highly impacted patients  suffer neuro-motor difficulties from childhood, and the less impacted, unfortunately face an untimely death when exposed to potent forms of Uracil such Effudex or fluorouracil.  dpd-deficiency dot com

Why did I start with “I am a Anaphylaxis-allergy condition person!” 3% of populations have Anaphylaxis-venom poisoning resulting in many sad side effects, one sad side effect is neuro-motor disabilities. (above) Not 1 in a 1,000 odds. But 3 in 100 odds; but what are the realities of the envenomization upon enzyme funtioning?. 

By comparison, I know from my personal experience that 99% of my friends and family have been bitten by a neuro-toxin venom insect! Yes, the odds are 99% you were too. Neuro-venom toxins are found in red ants, bees, wasps, hornets, etc.   Venom toxicityremains in the metabolism, BUT  the immune system keeps the toxins in check for years.   

The World Health Organization doesn’t want to hear this 99% scientific fact, for they received an estimated $100,000 donation to list 5FU Chemo Drug on their ‘approved drug list’.  Notice that 5FU was not a recommended Intraperitoneal hyperthermic chemoperfusion (IPHC) drug. It has a horrible history compared to the Mitomycin chemo family.  

           In my 8 years research, I realize most doctors have no clue about 5FU, the chemo / oncology doctors have no clue. They believe the propaganda that is published by the ‘Money-changers’. Don’t expect a moral and virtuous decision by a ‘Money-Changer Oncology Merchant’ as they want to make a buck the same as any Used-Car Merchant.

           I got to talk to the UCI Professor Oncologist who proposed to Congress 2004 as a Paid Expert Witness – ie ‘Money-Changer Chief Oncologist’  that the ‘Medical Findings of 5FU Clinical Trials over the last 30 years were by evidence collected and edited by the ‘Money-Changers’  were nowgiving a hopeless person and last-resort patient ‘a new and important choice’    where there was historically,    ‘no prior choice’    until, that is,   until 5FU / DNA-toxic drug came along.  ( read prior discussion with John and me above.)

 As you cry each night and can’t sleep, you may read more about this ‘cancer industry’ which does its best for patients and also does its worse for patients.   5FU may be the worse choice,  specially when you and your loved ones are deprived the Dpd Enzyme (99%) test.  Odd are not 1 in a 1,000.  These tests are very new, very inaccurate.   This discussion of the dangers of 5FU  must take place prior to doctors scaring the heck out of you in their  5FU Sales Presentation. 

Without powerful pain drugs and uppers I can barely get out of bed, the 5FU still erodes my chest, my heart, I have heart cramp attacks once a week, I have heart fibrillations almost every night associated with extreme fatigue. The doctor says “5FU will dissipate out of your body!”  Don’t believe it; they don’t know that, can’t test for that, and do not deserve your trust.   I have 5FU Chemo Brain and suffer from Venom-DNA toxifications complicated by the 5FU  ( 99% of us have DNA-altering venom impacts in our life). Some of us have stronger Immune Systems - Your fiancée being full Norwegian has nothing to do with this scientific discussion,  as your region has the same DNA-venomous conditions. 

          A new discovery can now identify snake venom DNA to specific species. Some day we will have a way to identify the biological DNA-altering toxins from each specific insect species.  Also see, cancers caused not from biological-toxins / google the list / for other causations – now that you can’t sleep. 

         Lov ya

Dave

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