Vitamin C supresses JAK 2 gene

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RE: Vitamin C supresses JAK 2 gene

by Gundi606 on Fri Mar 23, 2018 08:07 PM

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On May 31, 2011 12:56 AM dalt1 wrote:

I posted a while back how I turned around my myelofibrosis within a very short period using vitamin c and selenium and I have been asymptomatic for approx 1.5 years now.

Those MF sufferers will find hope with the following extract that medical research in 2002 (yes, nine years ago) it was discovered that vitamin c will supress the Jak 2 inhibitor gene that is suspected of triggering myelofibrosis.

I might add that major cancer institutes are rushing to find a supressor for the JAK 2 gene in the hope of making a lot of money. Why, when it is readily available now.

Read the extract and for those who want the full medical article to give to your oncologists, let me know and I will forward this to you. Don't be surprised that the oncologists will Pooh Pooh the research as there is no money in vitamin c injections, but there is in administering chemo drugs and bone marrow transplants -

Vitamin C inhibits granulocyte macrophage–colony-stimulating factor–induced signaling pathways
Juan M. Ca´rcamo, Oriana Bo´rquez-Ojeda, and David W. Golde
Vitamin C is present in the cytosol as ascorbic acid, functioning primarily as a cofactor for enzymatic reactions and as an antioxidant to scavenge free radicals.
Human granulocyte macrophage–colonystimulating
factor (GM-CSF) induces an increase in reactive oxygen species (ROS) and uses ROS for some signaling functions.
We therefore investigated the effect of vitamin C on GM-CSF–mediated responses.
Loading U937 cells with vitamin C decreased intracellular levels of ROS and inhibited the production of ROS induced
by GM-CSF. Vitamin C suppressed GM-CSF–dependent phosphorylation of the signal transducer and activator of
transcription 5 (Stat-5) and mitogenactivated protein (MAP) kinase (Erk1 and Erk2) in a dose-dependent manner as was
phosphorylation of MAP kinase induced by both interleukin 3 (IL-3) and GM-CSF in HL-60 cells. In 293T cells transfected with alpha and beta GM-CSF receptor subunits
(GMR and GMR), GM-CSF–induced phosphorylation of GMR and Jak-2 activation was suppressed by vitamin
C loading. GM-CSF–mediated transcriptional activation of a luciferase reporter construct containing STAT-binding sites was also inhibited by vitamin C.
These results substantiate the importance of ROS in GM-CSF signaling and indicate a role for vitamin C in downmodulating GM-CSF signaling responses. Our findings point to vitamin C as a regulator of cytokine redox-signal transduction in host defense cells and a possible role in controlling inflammatory responses.
(Blood. 2002;99:3205-3212)
© 2002 by The American Society of Hematology

I can be contacted through the contact section of "" target="_blank" rel="nofollow"> " target="_blank" rel="nofollow"> - reference Dalt - Jak 2/Vitamin C medical paper

Email me at 

For more info on treatment with Vitamin C intravenous and selenium 

Thank you


RE: Vitamin C supresses JAK 2 gene

by farmgal on Mon May 14, 2018 05:46 PM

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I was recently disgnosed with Essential Thrombocythemia and with JAK2 positive. I have tried to reach Dalt through e-mails posted on here and a website as well. I would love to know more about the protocol used to keep platelets down using vitamin c, selenium and bi-carb. I went to a health food store and got all but the bi-carb which they are trying to order for me. I have started with the vit c and selenium but don't know the amounts of each. I want to fight this now before my platelets get too high and have to use something like hydroxy or Anagrelide etc. Any info on this would be so greatly apprectiated!!!! I am all about natural ways to go about this. At this point the drs. are saying 81 mg of aspirin a day for me. 

Thank you for any help in this!

RE: Vitamin C supresses JAK 2 gene

by Jennifer56 on Mon Nov 11, 2019 05:22 AM

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Dear farmgal, I realize this is an older post, but did you have any luck with the vitamin C protocol? I am ET JAK2. Blessings!

RE: Vitamin C supresses JAK 2 gene

by jeff3 on Mon Nov 11, 2019 12:01 PM

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farmgal, click on the Myelofibrosis discussion and go to page post 139 and read to the bottom of the page where Stimme shares news about Dalt. You can benefit from the content of the Myelofibrosis discussion as it contains information you can apply to your current diagnosis. Regarding vitamin C, you will benefit more from liposomal vitamin C because it remains active far longer and is absorbed at a higher level than plain vitamin C. Commercially prepared liposomal vitamin C will allow you to sample it's effect by using 15 ml three times a day. My wife used Tocotreienol from red palm oil to lower her platelets while on Anagrelide that wasn't lowering the platelets. She used 100 mg with each meal. Delta Tocotrienol from annatto is also effective. Please learn all you can about tocotrienol.   

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