Anyone used 3bp (3-bromopyruvate)?

4703 Posts | Page(s): Prev 12...431 432 433 434 435 ...470471 Next 

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Mar 18, 2017 11:34 PM

Quote | Reply

There are quite a few back items that I am catching up on. Another one is how surprised I have been to read of how large some of the reported responses to 3-BP have been. Probably especially so for the Dayspring reports. It has always seemed to me that they were almost improbably large. They have reported large responses in a range of stage IV patients and I have not been unsure how credible such claims could be.

Recently one line of research that has helped me gain confidence relates to tumor evolution. There is an expected path tumors follow toward increased LDH, etc. It would appear that 3-BP could be expected to have more effectiveness in exactly those patients who would no longer have conventional treatment options.         

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sun Mar 19, 2017 01:14 AM

Quote | Reply

Remarkable!

Here it is hot off the press, using all the latest technology what did they find? PMID:28304380

... which seems remarkably appliable to PMID:21666701

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Mon Mar 20, 2017 12:33 AM

Quote | Reply

There is so much encouraging research being published!

http://ascopubs.org/doi/pdf/10.1200/JCO.2016.71.3024

Will we soon start to see such breakthrough research in typical solid cancers such as for example colorectal?

RE: Anyone used 3bp (3-bromopyruvate)?

by dumbcritic on Mon Mar 20, 2017 04:56 AM

Quote | Reply

On Mar 20, 2017 12:33 AM Jcancom wrote:

There is so much encouraging research being published!

http://ascopubs.org/doi/pdf/10.1200/JCO.2016.71.3024 "" target="_blank" rel="nofollow">http://ascopubs.org/doi/pdf/10.1200/JCO.2016.71.3024 " target="_blank" rel="nofollow">http://ascopubs.org/doi/pdf/10.1200/JCO.2016.71.3024

Will we soon start to see such breakthrough research in typical solid cancers such as for example colorectal?

Most CAR constructs are still chimeric or humanised 1st gen (CD28) versions. It would be nice to see most pharma companies in this space to start pursuing ''fully" human 2nd gen (CD28 + 4-1BB) controlled and armored versions and then build up from there. According to Jefferies pricing will be $300-$650,000

As for solid cancers then Adaptimmune is leading the TCR race with a number like Medigene behind them. The down side is both are targeting well known (public) antigens like MAGEA1, NY-ESO-1, etc and doing the gene transfer with lentiviral vectors. So this will be far most time-consuming, costly and could lead to antigen escape. Ziopharm on the other hand are using the sleeping beauty transposon system and will target neoantigens. The 2nd gen version by Zio will add membrane-bound IL-15. The only company using tumor infiltrating lymphocytes are Lion Biotechnologies.

As for neoantigen vaccines then two companies to watch are Immune Design and Advaxis. The former is buliding 2nd and 3rd gen versions of ZVex. This delivers RNA antigen(s) directly to dendritic cells in vivo. The newer versions can deliver multiple antigens, have a naturally increased immunogenicity and they could add certain adjuvants like IL-12 as well http://www.abstractsonline.com/pp8/#!/4292/presentation/2611 This could be combined with G100 http://www.abstractsonline.com/pp8/#!/4292/presentation/6397 The latter are using a live, attenuated bioengineered listeria monocytogenes bacteria to deliver the antigens.

RE: Anyone used 3bp (3-bromopyruvate)?

by dumbcritic on Mon Mar 20, 2017 12:33 PM

Quote | Reply

On Mar 18, 2017 11:14 PM Jcancom wrote:

It is encouraging that success with 3-BP has not been confined to a single center. The group below from Colombia have moved on to other treatment approaches, though apparently the patient below maintained the response at least for some time. It is actually quite reassuring the extent that other centers have also noted sucess with 3-BP.

http://www.prnewswire.com/news-releases/cancer-treatment-ins titute-of-colombia-demonstrates-unprecedented-results-using-unique-cancer-drug-combination-of-3-bromopyruvate-and-salinomycin-for-treatment-of-multiple-types-of-cancer-277467361.html"" target="_blank" rel="nofollow">http://www.prnewswire.com/news-releases/cancer-treatment-ins target="_blank" rel="nofollow">http://www.prnewswire.com/news-releases/cancer-treatment-ins

It's a shame a case report wasn't published

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Mon Mar 20, 2017 04:07 PM

Quote | Reply

critic, I am just feeling the love with these liquid biopsies. Wow!!!

We clearly needed a whole new team thinking about cancer and it looks like even near termish there could be a true cancer revolution. Amazing! We wouldn't need a microscope to see that cancer mortality stats have changed if this pans out.

RE: Anyone used 3bp (3-bromopyruvate)?

by nothingtolose on Mon Mar 20, 2017 08:33 PM

Quote | Reply

All,

im new to this thread. I have spinal mets from aggresssive testicular cancer and conventional radiotherapy and chemoterapy can't help me much.

Im not ready to give up yet. 

did any of you try oral 3-bp and if yes,what was your source please? Im currently on DCA  - cant tell if it helps or not after only 2 weeks, no side effects for sure.

I would not want to order 1kg from China  - can i order 10g-100g from somewhere?

Re preparation i have found a nice blog to help- but procuring seems a bit tricky at this point.

any help appreciated, thank you,

all the best.

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Tue Mar 21, 2017 12:00 AM

Quote | Reply

nothingtolose, I am sorry to hear of your situation.

I would certainly want to double check (even double double check) that traditional medicine is likely to no longer be help to you. Testicular cancer has shown that chemo (cisplatin etc.) can actually greatly help many of these patients. A real success sotry. It is greatly unfortunate that this is not as true for other cancers.  

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Tue Mar 21, 2017 01:03 AM

Quote | Reply

Anyone have any idea why the Dayspring website has been down for so long?

RE: Anyone used 3bp (3-bromopyruvate)?

by nothingtolose on Tue Mar 21, 2017 09:14 AM

Quote | Reply

On márc. 21, 2017 12:00 de. Jcancom wrote:

nothingtolose, I am sorry to hear of your situation.

I would certainly want to double check (even double double check) that traditional medicine is likely to no longer be help to you. Testicular cancer has shown that chemo (cisplatin etc.) can actually greatly help many of these patients. A real success sotry. It is greatly unfortunate that this is not as true for other cancers.  

if testicular cancer becomes resistant to cisplatin or it it reaches CNS  after 1st line chemo (my case) cisplatin based chemo cant offer much. this is why appr 10% of patients still die in most countries.  btw im aware of daniels great page.

as my nickname indicates im not worried about 3bp, or any side effect, im worried about my terminal cancer.

thank you for your reply

4703 Posts | Page(s): Prev 12...431 432 433 434 435 ...470471 Next 
Subscribe to this message board discussion

Latest Messages

View More

We care about your feedback. Let us know how we can improve your CancerCompass experience.