Anyone used 3bp (3-bromopyruvate)?

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RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Sat Jul 27, 2019 05:22 PM

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From the study:

"We performed a multiinstitutional Phase II cooperative group study of concentrated fish oil capsules that were obtained from the National Institutes of Health (NIH). In this study, a 70 kg patient was to receive 4.7 g EPA and 2.8 g DHA (as part of a total of 8.5 g omega-3 fatty acids) per day for > 1 month. We found that if a large dose of omega-3 fish oil fatty acid capsules was tolerable as a dietary supplement, then patients with cancer cachexia could experienced weight stabilization or weight gain."

I'm also adding three tablespoons fish oil to her high fat protein shake I have been making.

New recipe is 4 tablespoons MCT oil, 3 tablespoons fish oil, 1 tablespoon olive oil, 4 tablespoons heavy cream, 2oz cream cheese, 2 tablespoons unsweetened cocoa, 1 large scoop Simply Green chocolate protein power, 1 cup water, 1 cup ice.

Mix the protein powder and water first, then mix the cocoa and MCT oil in a separate bowl, then put everything into the blender.  Drink throughout the day, as that much MCT and fish oil taken too quickly can cause diarrhea.  Don't ask.  :)

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Mon Jul 29, 2019 01:00 PM

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J:

I was clicking around on Daniel's site and found a page on a possible treatment for cachexia using Dr. Gold's hydrazine.

I had heard of it before but didn't get into it.  Is anyone using it with success?

Daniel has a lot of links to explore on about it on this page (scroll down to just below his 27.06.2019 update and start reading about hyrazine):

https://www.cancertreatmentsresearch.com/addressing-gluconeo

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Tue Jul 30, 2019 12:24 AM

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JohnnyP, yes there was a modest response reported by anca in the first reply on that thread. Strangely, we have not had many posters on D's forum discussing cachexia, so I will follow your exploration of this aspect of cancer management carefully.

Your post has sparked an interest in how we could use upgrade our thread to help people more effectively locate information. This is somewhat in reference to my reading about how the Korean language came into being. Apparently, on January 1st, 1500 sometime around 9:00 AM everyone in Korea started speaking Koeran. Basically those in authority declared that this was the way it had to be and the people went along with it.

The linkage I see to our ongoing exploration of cancer is that we (or I guess more formally ME) could change our posting habits in order that the valuable information on our forum and on D's forum and possibly elsewhere could easily extracted by introducing particular formatting.

Here's the way it could work for your hydrazine, cachexia idea. We could format it perhaps as                 (hydrazine(!?), cachexia, Jcancom(2)). What that is saying is hydrazine as a possible treatment for cachexia with 1 exclamation mark and 1 question mark, suggested by (or in this instance seconded) by Jcancom.

How would this help making finding information on the thread easier to locate? Well, I have tried out some webcrawlers on this site which I could use to upload the contents of the thread to my computer or alternatively we could also upload the content to the wikia for 3-BP. Once we have the content to work with then the formatting would be an efficient way to locate relevant information from the thread (e.g. find (Hydrazine).)

One of the big problems that everyone confronts is the sheer scale of the research literature on cancer. It is this vast ocean of research that is completely unmanageable. With the codings that I have suggested one could easily located the gems on our thread and elsewhere with not much exertion. That really should be the driving passion of the thread: make it easier for others who are struggling with the same massive research dataset that we are struggling with.

critic mentioned E260 as a selective OXPHOS agent awhile back. I would probably give that one at least four exclamation marks! What do you think of this idea?

Best Wishes, Jcancom     

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Wed Aug 07, 2019 08:56 PM

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Good news, Shirley's CA15-3 cancer marker only went up two points this month, to 89, high normal is 25.  And, she put on two pounds.

I've been giving her a tablespoon of fish oil every six hours, when she takes her pain med.

We met with her oncologist's PA yesterday.  I asked her about getting a prescription for dipyridamole.  When she asked what it was for, I told her it's a blood thinner to prevent platelets from trapping cancer stem cells in the capillaries.  She said the oncologist will not prescribe it because "it's not indicated" as a cancer treatment by the FDA.

I told her with the FDA approved treatment most patients die in two-three years.  She said yes, most die in two or three years but if you take this drug you might die sooner.

I said that risk should be up to us.

She said she understands how I feel, as she was the same way when her father was diagnosed with prostate cancer.  He is still living after six years of standard treatment, though she added she is giving him Resveratrol.

RE: Anyone used 3bp (3-bromopyruvate)?

by Lauras777 on Wed Aug 07, 2019 09:03 PM

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Dear Johnny & Shirley,

Just wanted to tell you thoughts & prayers are sent out to you both. I've dealt with my cancer and that of my huband. It's a horrible disease and I think you are both doing great things! Keep up the fight!!

Laura

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Wed Aug 07, 2019 09:35 PM

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Thank you so much.  I'm sorry you lost your husband.

Whatever happened to 3BP?  It would be nice to get an update from Dr. Ko.

I've been looking into metformin in combination with syrosingopine, an old blood pressure drug.  I posted about it earlier.

The combination was recently patented, but I've heard the drug company is not interested in marketing it, since both drugs are off patent.

The syro is available from China but you have to spend $1500 for one gram.  It works out to about $12 a day for a 125 day supply.

RE: Anyone used 3bp (3-bromopyruvate)?

by Lauras777 on Wed Aug 07, 2019 10:09 PM

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I actually spoke to Dr. Ko on the phone. I think it was too far along at that point. We did go to Germany for stem cell and although it didn't work on my hsband I know of 3 others who are doing fine.

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Aug 08, 2019 01:09 AM

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JohnnyP, always great to hear great news from you! I am so glad that you continue to find new treatment possibilities. Standing still is clearly not a strategy one want to try with cancer.

It really is an enormous frustration when these prescription roadblocks cause a traffic jam on the freeway. How much clearer does the democratic process have to be than the Right to Try nationwide mandate? This allowed drugs that had only completed a phase 1 trial! I do not see how a legal challenge would rule in any way other than to accept off-label prescribing for FDA approved medications. There are a range of Right to Try sequels that might need to be embraced by grassroots activists.

I have not heard of any formulations for Feb and syro, though I suspect that they could add yet more potency and specificity.

Best Wishes, J

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Aug 08, 2019 01:39 AM

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Laura, I am sorry to hear of your loss.

After several years of our efforts, we are beginning to see a number of responses to metabolic approaches (especially on D's forum). The building momentum behind this strategy would seem undeniable. Once a 3-BP formulation were firmly in clinical trials my guess would be that an entire ecosystem of synergistics would rapidly materialize: Almost anything would likely have a chance at efficacy in combination with 3-BP.

Sending kind thought to you, Jcancom

RE: Anyone used 3bp (3-bromopyruvate)?

by JohnnyP on Thu Aug 08, 2019 11:45 PM

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I have been emailing back and forth with a guy on another forum that is using metformin in combination with syro.

The combination was recently patented.  A comment from my pen pal about this:

Prof Dr Dom Benjamin in switzerland who discovered syro works with metformin was paid by a pharmisutical Co to discover a drug to go with metformin. when the only one turned out to be syro they shelved it. no profit in it both metformin and syro have patents that have run out.  any body can make it..  The whole cancer industry is controle by big Pharma and money as you have discovered
wish you the best
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