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Jcancom's Recent CancerCompass Activity

  • Jcancom has replied to a post on the message board

    critic, yes the NKTR deal is huge! I did not want to mention it because I might have overdone my enthusiasm on my last post about 214, though with the latest deal perhaps my comments were on the mark. It is very impressive that as you noted it will be investigated in 9 tumor indications. Immunological drugs have a wider range of targets than I had anticipated. The feeling that I have now is that we are sprinting to ...

    February 17 at 5:52 PM view post
    • Jcancom has replied to a post on the message board

      Dear finder, I am surpised that the media has not yet recognized this as a potential story. It is probably even more surprising that the investigators have not moved ahead of such a story by making a preemptory statement about whatever has been determined so far about the potential of TLS in the Bracht incident. It would be important to clarify this because the entire nature of the investigation would greatly change...

      February 11 at 9:31 PM view post
      • Jcancom has replied to a post on the message board

        finder, is there anything on this in the Dutch mediaspace? There is a growing glow on D's site. If Bracht was TLS, then it changes everything. The above url, "3-BP nicht verantwortlich" said it was not impure 3-BP. What then? TLS surely would then spring to mind. Have the investigators officially ruled out TLS? Would they be under a legal obligation to the community to make a timely disclosure if they had found evide...

        February 09 at 12:28 AM view post
        • Jcancom has replied to a post on the message board

          I have refrained from commenting extensively on Bracht while the investigation has been ongoing. I wanted to give enough time for a thorough examination of the evidence. It has been almost two years and a report has yet to be produced. However, there appears to be an evolving understanding of what might have happened that I want to post. From url below:  "Medienberichten zufolge sollen Verunreinigungen von 3-B...

          February 08 at 2:05 AM view post
          • Jcancom has replied to a post on the message board

            critic, you made my day again! A 100% DCR?!!! That is awesome! My ongoing comment about ccRCC is that it makes no sense to me. A ways back on the thread it was noted that ccRCC was found to have essentially no mitochondria!! How is it possible that kidney cancer can be somewhere near a top ten cancer type with clear cell RCC being the biggest subcomponent when it is so metabollically weak? The Scottish trial with ...

            February 08 at 1:30 AM view post
            • Jcancom has replied to a post on the message board

              Critic, it looks as though all the pharmas are highly aware of this opportunity. The phase 1 trials with OX40 amount to a few thousandpatients. The therapeutic potential of OX40 anti-bodies must have been obvious to them for at least the last 5 years.   The article below gives a strong argument for the therapeutic potential of a TLR9 OX40 combo. The article reports that TLR9 could be replaced by TLR7/8, though...

              February 03 at 11:00 PM view post
              • Jcancom has replied to a post on the message board

                Might this this be the one? TLR9 and OX40. This results in a tumor specific response without expected side effects. Might already be available under the terms of Right to Try law. https://www.sciencedaily.com/releases/2018/01/180131184751.htm

                February 02 at 3:00 AM view post
                • Jcancom has replied to a post on the message board

                  finder, it's great that you are back on thread! The ground continues to shift on the frontier of cancer treatment, so it's always helpful to have people on the lookout for these changes. German rationalism. That is my best post facto explanation for why Germany has a Right to Try interpretation that involves mice (and cells?). The philosophical traditions of a culture have a habit of working their way into their po...

                  January 25 at 2:03 AM view post
                  • Jcancom has replied to a post on the message board

                    critic, are they serious "We're going to research this for another 5 years?". After another 40 million people have died from cancer? I am sure that there is a multi-billion dollar market for this technology now even if it were to be sold as is. And exactly what is the logic and the moral justification for not allowing this to launch right now? A blood draw is thought of as being to high a cost for such a benefit?&nbs...

                    January 20 at 5:35 PM view post
                    • Jcancom has replied to a post on the message board

                      finder, Thank you! Our thread has really missed the boat on this aspect of German and Dutch medical law. I appologize to readers of the thread for not picking up on this earlier. I realize for several posters that this would have made the difference between being alive and not being alive. If 22nd Century treatments are allowed, then treating cancer becomes easy. All these thousands of posts on our thread have bee...

                      January 20 at 12:31 AM view post
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