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Mkk2018's Message Board Messages

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On Feb 28, 2020 7:31 PM PhilipJax wrote:

Mkk2018,
          Thanks.  Please give links to the trial reports that you cite, the Phase 1 & 2 trial reports showing good performance for “SBRT in combination with immuno+parp” in metastatic cases (or BRCA cases, if you wish).
          Also, I do not understand your following two statements.  I hope you will take a moment to clarify:
1. but not everyone follows under those guidelines:” The Decision Guide addresses all disease stages and multiple lines of therapy, and the posts on past ASCO symposia address literally scores of research abstracts.  Virtually every case is addressed.
2. If you have information to support this:” Please tell me what you mean by “information to support this”?  Support what?
         PhilipJax

For sure. I just know that although your steps are extensive sometimes the route they suggest as far as finding treatment just is not working for everyone. Hence, us and it is. Rey hard to hear from other “don’t go that route”. It does address multiple lines of therapy but there are other lines out there. Immuno+Parp and SBRT just to name one. And yes the posts on ASCO symposia is fantastic also of which some do support what we are doing. Thank you for your posts and information! I will provide our sources we have looked at when we are ready. Anyone is able to search the combinations or contact other oncologists as ours do for some information ! Thanks so much for your extensive research in pan.can I read your information and search further some things you suggest! Thank you!

RE: nanoknife IRE for pancreatic cancer

by Mkk2018 - February 28 at 6:50 PM

On Feb 25, 2020 7:14 PM PhilipJax wrote:

Mkk2018,
          Have you studied the Decision Guide and my last 2 years of posts as yet?  That means studying every line and every reference.  It takes a lot of work.  But, there are rewards: If there is an answer, that is where it will be found.
          I prepared the Guide and created the CancerCompass posts (taking scores of hours of work) to answer such questions as yours.  The best answer is within those two sources.
          For example, using those sources (1) a patient recently pursued a peritoneal metastases therapy; (2) another added Cisplatin to a common combination; (3) others have taken advantage of the new willingness to treat metastases when they are few; (4) another has enrolled in the hard-to-enter BATs trial, and (5) another is investigating hepatic arterial 5FU infusion combined with systemic chemotherapy. 
          You do not have to limit yourself to BRCA targeting.
         PhilipJax

Yes - and we are treating metastases as there are few, but 2 significant spots we need to stop/kill and or stablize - similar to your option 3, of this new willingness. That is our plan right now. The pancreas (original tumor) is atrophic. 

RE: nanoknife IRE for pancreatic cancer

by Mkk2018 - February 28 at 6:46 PM

For sure I have studied it but not everyone follows under those guidelines. For example, we are not venturing with Cisplatin as we have too much neuropathy discomfort from previous Folfirinox. So that's done. 

We have done much research WITH our oncologist and team of experienced individuals and actually have data supporting phase 2 and 3 trials for SBRT in combination with immuno+parp. You have to step out of the box and standard of care if you want something to happen instead of following always the plans that others have done. Being BRCA does allow you to do this. Clearly. 

It isn't as if we just listen to the doctors and just agree right away with their plan - we always discuss options and plans.  Eventually after progression on standard of care you need to move on. In order to get to surgery we need to stop what is happening if it is not being done so by standard chemo. We need things to stop and be stable.

If you have information to support this, we'd welcome that discussion and conversation.

RE: nanoknife IRE for pancreatic cancer

by Mkk2018 - February 22 at 3:57 AM

Just sent a new email :)

RE: nanoknife IRE for pancreatic cancer

by Mkk2018 - February 22 at 3:29 AM

With a BRCA mutation **

RE: nanoknife IRE for pancreatic cancer

by Mkk2018 - February 22 at 3:28 AM

I’m not sure how else we should proceed. The GTX chemo we were on does not seem to be stopping things the way it should be. And the liver metastasis is growing. Where else do we realistically go from here ... either BRCA mutation. We need to be acting quickly.

RE: nanoknife IRE for pancreatic cancer

by Mkk2018 - February 17 at 5:44 PM

This is great. I will closely at all of this. Any input on radiation And immunotherapy combination for pancreatic?? This is the route we are headed I believe now

RE: nanoknife IRE for pancreatic cancer

by Mkk2018 - February 14 at 2:03 PM

Hi! I thought it was my fault sending it to a wrong email! Could I resend from a gmail account? Would that be better?

RE: nanoknife IRE for pancreatic cancer

by Mkk2018 - February 13 at 5:42 PM

I was just wondering about this - I was thinking it was me sending it to the wrong address. I’ll resend it from another address - Gmail account. Should that work ?

RE: nanoknife IRE for pancreatic cancer

by Mkk2018 - February 10 at 9:11 PM

Fabulous - I just sent an email now! Thank you <3
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